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The increased levels of ROS can promote pro-survival and pro-proliferative pathways as well as the metabolic adaption of tumor cells to the tumor environment [99]

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For acute stimulation experiments, cells were cultured with LPS and IFN- for 2 h, after which stimuli were removed, cells were washed with Dulbeccos PBS (dPBS), and cell culture was continued in fresh media without stimuli for the remaining time course

A comprehensive understanding of the intricate interplay between ROS and antioxidant defense systems, such as GSH, is crucial for elucidating disease progression and developing potential therapeutic strategies in lung cancer